U.S. Law of the Sea Cruise to Map the Foot of the Slope of the Northeast U.S. Atlantic Continental Margin: Leg 6

U.S. Law of the Sea Cruise to Map the Foot of the Slope of the Northeast U.S. Atlantic Continental Margin: Leg 6 Cruise KNOX17RR May 1 – 31, 2008 Ft. Lauderdale, FL to Woods Hole, M

U.S. Law of the Sea Cruise to Map the Southern Flank of the Kingman Reef-Palmyra Atoll section of the Line Islands, Equatorial Pacific Ocean

U.S. Law of the Sea Cruise to Map the Southern Flank of the Kingman Reef-Palmyra Atoll section of the Line Islands, Equatorial Pacific Ocean CRUISE KM1009 May 17, to June 16, 2010 Pago Pago, American Samoa to Honolulu, H

U.S. Law of the Sea Cruise to Complete the Mapping of Necker Ridge, Central Pacific Ocean

U.S. Law of the Sea Cruise to Complete the Mapping of Necker Ridge, Central Pacific Ocean CRUISE KM1121 July 31, to August 10, 2011 Honolulu, HI to Honolulu, H

Analysis of signalling pathways using the prism model checker

We describe a new modelling and analysis approach for signal transduction networks in the presence of incomplete data. We illustrate the approach with an example, the RKIP inhibited ERK pathway [1]. Our models are based on high level descriptions of continuous time Markov chains: reactions are modelled as synchronous processes and concentrations are modelled by discrete, abstract quantities. The main advantage of our approach is that using a (continuous time) stochastic logic and the PRISM model checker, we can perform quantitative analysis of queries such as if a concentration reaches a certain level, will it remain at that level thereafter? We also perform standard simulations and compare our results with a traditional ordinary differential equation model. An interesting result is that for the example pathway, only a small number of discrete data values is required to render the simulations practically indistinguishable

A method of isolating organic compounds present in water

Water sample is passed through a column containing macroreticular resin, which absorbs only nonionic organic compounds. These compounds are selectively separated using aqueous eluents of varying pH, or completely exuded with small amount of an organic eluent

Seafloor mapping in the Arctic: support for a potential U.S. extended continental shelf

For the United States, the greatest opportunity for an extended continental shelf under UNCLOS is in the ice-covered regions of the Arctic north of Alaska. Since 2003, CCOM/JHC has been using the icebreaker Healy equipped with a multibeam echosounder, chirp subbottom profiler, and dredges, to map and sample the region of Chukchi Borderland and Alpha-Mendeleev Ridge complex. These data have led to the discovery of several new features, have radically changed our view of the bathymetry and geologic history of the area, and may have important ramifications for the determination of the limits of a U.S. extended continental shelf under Article 76

Association study of single nucleotide polymorphisms in IL-10 and IL-17 genes with the severity of microbial keratitis

PURPOSE Exploratory analysis to assess the association of single nucleotide polymorphisms (SNPs) in the interleukin (IL) 10 and IL-17 genes with severity of contact lens keratitis. METHODS This was a retrospective case control study of 88 contact lens keratitis cases (25 severe) and 185 healthy contact lens wearers recruited from studies conducted at Moorfields Eye Hospital and in Australia-wide during 2003–2005. Buccal swab samples were collected on Whatman FTA cards and mailed by post for DNA extraction and SNP genotyping. IL-10 (rs1800871; rs1800896; rs1800872) and IL-17 (rs1800871; rs1800896; rs1800872) SNPs were screened by pyrosequencing. Genetic association analyses were performed via Cochran-Armitage trend tests and logistic regression models using PLINK software. RESULTS None of the SNPs tested showed evidence of association with severity of contact lens keratitis at P <  0.05. Nevertheless, minor allele G in SNP rs2397084 of the IL-17F gene was associated with increased risk of severe MK, with OR=2.1 (95% CI=0.9-4.8, P = 0.066). CONCLUSION Our study cannot exclude with confidence that genetic variation in the IL-17 F proinflammatory cytokine is associated with more severe outcomes of MK. However, there is general body of information that the IL-17 pathway is important in the mechanisms of MK. Studies with larger power and the expanded array of laboratory tools will elucidate the exact role of IL-17 in MK

Hatteras Transverse Canyon, Hatteras Outer Ridge and environs of the U.S. Atlantic margin: A view from multibeam bathymetry and backscatter

Previously unknown features in Hatteras Transverse Canyon and environs were recently mapped during multibeam surveys of almost the entire eastern U.S. Atlantic continental margin. The newly identified features include (1) extensive landslide scarps on the walls of Hatteras Transverse and Hatteras Canyons, (2) an area of multiple landslide deposits that block lower Hatteras Transverse Canyon, (3) a large depositional feature down-canyon from the landslide deposits that rises 100 m above the uppermost Hatteras Fan and has buried the transition from the mouth of Hatteras Transverse Canyon to uppermost Hatteras Fan, (4) a zone of cyclic steps on upper Hatteras Fan that suggests super critical turbidity currents performed a series of hydraulic jumps and formed large upstream-migrating bedforms, (5) several knickpoints in the channel thalwegs of both Hatteras Transverse Canyon and Hatteras Canyon, one 40 m high, that suggest both canyon channels are out of equilibrium and are in the process of readjusting, either to the channel blockage by the extensive landslide deposits or by a readjustments to increased sedimentation during the last eustatic lowstand, (6) a large area of outcrop on the lower margin between Pamlico and Hatteras Canyons that previously was interpreted as an area of slumps, blocky slide debris and mud waves, (7) headward erosion in the head region of Hatteras Transverse Canyonwhere it has intercepted the lowest reaches of Albemarle Canyon channel as well as headward erosion in a small side channel that has eroded into Hatteras Outer Ridge and (8) sections of bedforms on Hatteras Outer Ridge that are partially buried by sediment from Washington–Norfolk Canyon channel as well as by sediment transported from Hatteras Abyssal Plain. The newly discovered features add a new level of detail to understand the recent processes that have profoundly affected Hatteras Transverse Canyon, Hatteras Canyon and, to a lesser degree, Hatteras Outer Ridge